Prostate Artery Embolization

What is an enlarged prostate (BPH)?

Benign prostatic hyperplasia (BPH) is the enlargement of the prostate gland that affects men as they age. The growing prostate squeezes the urethra (urine tube) and makes it harder for urine to flow. Prostate Artery Embolization is a non surgical treatment for BPH. Watch the video to see how an enlarged prostate can affect urination and how Prostate Artery Embolization can treat it.

GENERAL OVERVIEW

What symptoms are associated with BPH?

Most Common symptoms include:

  • Weak or slow urine stream
  • Difficulty starting urination
  • Urinating often, especially at night
  • Feeling like the bladder doesn’t empty completely
  • Urgency or sudden strong need to urinate

These are called lower urinary tract symptoms (LUTS) from BPH.

What is Prostate Artery Embolization (PAE)?

Prostate Artery Embolization is a minimally invasive, non-surgical procedure performed by an interventional radiologist to treat BPH. Through a tiny catheter in an artery, the doctor blocks the small blood vessels that feed the prostate, essentially coming off the blood supply to the prostate, causing it to shrink which relieves the urinary symptoms.

How does PAE help improve urinary symptoms?

By reducing blood flow, the prostate gradually shrinks over weeks to months. As the prostate gets smaller, pressure on the urethra decreases, so urine flows more easily and symptoms such as frequency, urgency, and nighttime urination improve. Watch the video to see how PAE works.

PATIENT ELIGIBILITY

Who is a good candidate for PAE?

Good candidates typically are men who:

  • Have moderate to severe urinary symptoms from BPH
  • Have a prostate that is enlarged on imaging
  • Want to avoid or are not satisfied with medications
  • Prefer a minimally invasive alternative to surgery
  • Do not want any sexual side effects from surgical interventions

Evaluation usually includes symptom questionnaires, labs, and imaging (such as MRI or Ultrasound).

Is PAE an option for men who want to avoid surgery or long-term medications?

Yes. Multiple studies and a multisociety position statement (Society of Interventional Radiology and American urological Association) support PAE as a safe, effective option for appropriately selected patients who want to avoid surgery or long-term medications.

Can PAE help men who are not candidates for TURP or other prostate surgeries?

Yes. PAE is often considered for men who are high-risk for anesthesia, have significant medical conditions, are on blood thinners, or have very large prostates where standard surgery is more difficult. It can provide symptom relief in many men who are not ideal candidates for TURP or laser procedures.

Does PAE help men with urinary retention or who use a catheter?

Many studies show that PAE can help men who are dependent on a urinary catheter due to BPH. A significant proportion of catheter-dependent patients are able to come off the catheter after PAE, once the prostate shrinks and obstruction improves.

Who should not undergo PAE?

PAE may not be appropriate for men who:

  • Have suspected or known prostate cancer as the main cause of symptoms
  • Have severe vascular disease that makes catheter access impossible
  • Have active urinary tract infection not yet treated
  • Are unable to lie flat or safely undergo moderate sedation

Your interventional radiologist and urologist will review your imaging and medical history to decide if PAE is right for you.

PROCEDURE DETAILS

How is the PAE procedure performed?

An interventional radiologist guides a thin catheter from an artery in the wrist or groin into the small arteries that supply the prostate. Tiny particles are injected to reduce blood flow to the prostate on both sides. The procedure is done using live X-ray guidance in an outpatient angiography suite. Watch a video to see how PAE is performed.

What type of anesthesia or sedation is used?

PAE is usually performed with local anesthetic at the catheter entry site and moderate or deep sedation through an IV. You are sleepy and relaxed but breathing on your own, avoiding the need for general anesthesia in most patients.

How long does the PAE procedure take?

Most PAE procedures take about 1 to 2 hours, depending on your anatomy and how easy it is to reach the prostate arteries. You will also spend some time in recovery afterward, and will go home the same day.

Where is the catheter inserted?

The catheter is most commonly inserted through a small puncture in the wrist (radial artery) or groin (femoral artery). The puncture site is only a few millimeters wide and does not require stitches or produce scars.

What materials are used to block the prostate arteries?

Tiny medical-grade particles (microspheres) are injected into the prostate arteries. These inert particles are designed to safely lodge in the small vessels, reduce blood flow, and trigger gradual shrinkage of the prostate tissue.

EFFECTIVENESS OF PAE

How effective is PAE in improving urinary symptoms?

Systematic reviews and randomized trials report significant improvement in symptom scores, quality of life, and urine flow in most men after PAE, with response rates typically around 80%.

How quickly will I notice symptom improvement after PAE?

Some men notice better flow and less urgency within days to weeks, while for others improvement is gradual over 1–3 months as the prostate shrinks.

How long do the benefits of PAE last?

Studies following patients for 3–10 years show that most men maintain meaningful symptom relief, although some may need repeat treatment or other procedures over time.

Can PAE be repeated if symptoms come back?

Yes. If symptoms return and imaging shows regrowth or new blood supply, PAE can often be safely repeated, or other BPH treatments can be considered based on your goals, clinical symptoms and anatomy.

How does PAE compare to medications, TURP, Urolift, or laser surgery?

  • Compared with medications: PAE can offer stronger and more durable symptom relief for men who fail or are tired of pills.
  • Compared with TURP / laser surgery: PAE generally has fewer hospital days, less bleeding, and lower risk of incontinence and sexual side effects such as retrograde ejaculation, but TURP may produce slightly greater improvement in flow on testing.
  • Compared with Urolift / Rezūm: Network meta-analyses suggest PAE provides symptom improvement similar to or better than some minimally invasive options for selected men, particularly those with larger prostates.

What are the advantages of PAE over surgery?

Key advantages of PAE include:

  • Outpatient procedure with tiny skin puncture (no surgical incision)
  • Usually no need for general anesthesia
  • Lower risk of bleeding and infection
  • Extremely low rates of sexual side effects such as erectile dysfunction or retrograde ejaculation
  • Faster recovery

RISKS & SAFETY

What are the risks or complications of PAE?

Most side effects are mild and temporary, such as pelvic discomfort, urinary frequency, burning with urination, or small amounts of blood in the urine or semen. Rare but more serious risks include non-target embolization (blocking the wrong artery), infection, or damage to blood vessels, which are uncommon in experienced centers.

How safe is PAE compared to traditional prostate surgery?

Randomized trials and large registries show lower rates of major complications with PAE compared to TURP, especially regarding bleeding, need for transfusion, and hospital length of stay. Overall, PAE has a much favorable safety profile compared to surgery when performed by experienced interventional radiologists.

Are there any sexual function side effects?

Most studies show significantly low rates of erectile dysfunction and retrograde ejaculation with PAE compared with TURP and some laser procedures. Many men report stable or even improved sexual satisfaction as urinary symptoms improve.

RECOVERY & AFTERCARE

What is the recovery time after PAE?

Patient go home the same day. Many men feel well enough for light activities within 1–3 days and experience mild pelvic or urinary discomfort for up to a week, managed with oral medications.

How soon can I return to normal activities?

You can usually return to desk work and gentle activities within a few days and gradually resume exercise over 1–2 weeks, based on how you feel and your doctor’s advice. Heavy lifting should be avoided for several days to protect the artery puncture site.

COMPARISONS & ALTERNATIVES

PAE vs. TURP: What are the key differences?

  • PAE: No surgical cutting of the prostate, tiny artery puncture, less bleeding, shorter recovery, better preservation of sexual function, but slightly smaller improvements in flow on urodynamic testing.
  • TURP: Long-standing gold standard, strong symptom and flow improvements, but higher risk of bleeding, sexual side effects, and need for hospital stay or catheter afterward.
Both are effective; choice depends on your anatomy, health, and priorities.

PAE vs. medications: When should someone consider switching?

You might consider PAE if:
  • Medications only partially improve symptoms
  • You have side effects like dizziness, low blood pressure, or sexual side effects
  • You want a more durable option that doesn’t require daily pills
PAE can often reduce or eliminate the need for BPH medications in many men.

PAE vs. minimally invasive options (Urolift, Rezūm, laser procedures)

All of these are less invasive than open surgery, but they differ in how they work, anesthesia needs, and long-term data. PAE is particularly attractive for men with larger prostates or higher surgical risk, with data suggesting comparable symptom relief and good sexual function preservation for many patients.

LONG-TERM CONSIDERATIONS

What is the long-term success rate of PAE in clinical studies?

Large single-center series and meta-analyses show durable improvement in symptoms and quality of life for most men, with clinical success in roughly 70–80% at 3–5 years and acceptable retreatment rates.

Will urinary symptoms return over time?

Some men may experience gradual return of symptoms over several years due to ongoing aging and prostate changes. If this happens, options include repeat PAE, medications, or other procedures depending on your situation.

Can PAE be repeated if symptoms return?

Yes. Many centers safely perform repeat PAE when symptoms recur and imaging confirms the need; outcomes are generally good, although data are more limited than for first-time PAE.

How much prostate shrinkage can I expect after PAE?

On average, studies report 20–40% reduction in prostate volume over 6–12 months, though the exact amount varies from person to person. Even moderate shrinkage can lead to large improvements in symptoms and quality of life.

LOGISTICS & COST

Is PAE covered by insurance?

Insurance coverage is improving as more evidence supports PAE. Many commercial insurers and some health systems now cover PAE; Medicare coverage is region-dependent. Our team at Florida Interventional Institute can check your specific plan and obtain pre-authorization when needed.

How do I prepare for the procedure?

Before PAE, you will typically:

  • Have blood tests, imaging (MRI/CT or ultrasound), and sometimes urodynamic testing
  • Review your medications (especially blood thinners) with your doctor
  • Receive instructions about fasting before the procedure and arranging a ride home

Our staff will provide a clear checklist tailored to you.

Do I need a referral from my doctor?

In many cases, a referral from your primary care doctor or urologist is helpful and may be required by insurance, but some patients can self-refer. We work closely with your other doctors to ensure coordinated, comprehensive BPH care.

KEY SCIENTIFIC REFERENCES

You can click these PubMed links to read more detailed medical data:

Clinical Practice Guidelines & Consensus Statements

  1. Sandhu JS, Bixler BR, Dahm P, et al. Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia (BPH): AUA Guideline Amendment 2023.J Urol.2024;211(1):11-19. doi:10.1097/JU.0000000000003698

    https://pubmed.ncbi.nlm.nih.gov/37706750/

  2. McWilliams JP, Bilhim TA, Carnevale FC, et al. Society of Interventional Radiology Multisociety Consensus Position Statement on Prostatic Artery Embolization for Treatment of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia.J Vasc Interv Radiol.2019;30(5):627-637.e1. doi:10.1016/j.jvir.2019.02.013

    https://pubmed.ncbi.nlm.nih.gov/30926185/

Cochrane Review & Systematic Reviews/Meta-Analyses

  1. Jung JH, McCutcheon KA, Borofsky M, et al. Prostatic Arterial Embolisation for the Treatment of Lower Urinary Tract Symptoms in Men with Benign Prostatic Hyperplasia.Cochrane Database Syst Rev.2022;3:CD012867. doi:10.1002/14651858.CD012867.pub3

    https://pubmed.ncbi.nlm.nih.gov/35696302/

  2. Malling B, Røder MA, Brasso K, et al. Prostate Artery Embolisation for Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis.Eur Radiol.2019;29(1):287-298. doi:10.1007/s00330-018-5564-2

    https://pubmed.ncbi.nlm.nih.gov/29948079/

  3. Ini’ C, Vasile T, Foti PV, et al. Prostate Artery Embolization as Minimally Invasive Treatment for Benign Prostatic Hyperplasia: An Updated Systematic Review.J Clin Med.2024;13(9):2530. doi:10.3390/jcm13092530

    https://pubmed.ncbi.nlm.nih.gov/38731058/

Randomized Controlled Trials

  1. Pisco JM, Bilhim T, Costa NV, et al. Randomised Clinical Trial of Prostatic Artery Embolisation Versus a Sham Procedure for Benign Prostatic Hyperplasia.Eur Urol.2020;77(3):354-362. doi:10.1016/j.eururo.2019.11.010

    https://pubmed.ncbi.nlm.nih.gov/31831295/

  2. Abt D, Hechelhammer L, Müllhaupt G, et al. Comparison of Prostatic Artery Embolisation (PAE) Versus Transurethral Resection of the Prostate (TURP) for Benign Prostatic Hyperplasia: Randomised, Open Label, Non-Inferiority Trial.BMJ.2018;361:k2338. doi:10.1136/bmj.k2338

    https://pubmed.ncbi.nlm.nih.gov/29921613/

  3. Abt D, Müllhaupt G, Hechelhammer L, et al. Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: 2-Yr Outcomes of a Randomised, Open-Label, Single-Centre Trial.Eur Urol.2021;80(1):34-42. doi:10.1016/j.eururo.2021.02.008

    https://pubmed.ncbi.nlm.nih.gov/33612376/

  4. Gao YA, Huang Y, Zhang R, et al. Benign Prostatic Hyperplasia: Prostatic Arterial Embolization Versus Transurethral Resection of the Prostate—A Prospective, Randomized, and Controlled Clinical Trial.Radiology.2014;270(3):920-928. doi:10.1148/radiol.13122803

    https://pubmed.ncbi.nlm.nih.gov/24475799/

  5. Insausti I, Sáez de Ocáriz A, Galbete A, et al. Randomized Comparison of Prostatic Artery Embolization Versus Transurethral Resection of the Prostate for Treatment of Benign Prostatic Hyperplasia.J Vasc Interv Radiol.2020;31(6):882-890. doi:10.1016/j.jvir.2019.12.810

    https://pubmed.ncbi.nlm.nih.gov/32249193/

  6. Sapoval M, Thiounn N, Descazeaud A, et al. Prostatic Artery Embolisation Versus Medical Treatment in Patients with Benign Prostatic Hyperplasia (PARTEM): A Randomised, Multicentre, Open-Label, Phase 3, Superiority Trial.Lancet Reg Health Eur.2023;31:100672. doi:10.1016/j.lanepe.2023.100672

    https://pubmed.ncbi.nlm.nih.gov/37415648/

  7. Brown N, Kiosoglous A, Castree S, et al. The P-Easy ADVANCE Trial: A Randomised Controlled Trial of Prostate Embolisation vs Medication for BPH.BJU Int.2024;134 Suppl 2:38-46. doi:10.1111/bju.16479

    https://pubmed.ncbi.nlm.nih.gov/39139009/

Large Cohort Studies & Registries

  1. Pisco JM, Bilhim T, Pinheiro LC, et al. Medium- and Long-Term Outcome of Prostate Artery Embolization for Patients with Benign Prostatic Hyperplasia: Results in 630 Patients.J Vasc Interv Radiol.2016;27(8):1115-1122. doi:10.1016/j.jvir.2016.04.001

    https://pubmed.ncbi.nlm.nih.gov/27321890/

  2. Ray AF, Powell J, Speakman MJ, et al. Efficacy and Safety of Prostate Artery Embolization for Benign Prostatic Hyperplasia: An Observational Study and Propensity-Matched Comparison with Transurethral Resection of the Prostate (The UK-ROPE Study).BJU Int.2018;122(2):270-282. doi:10.1111/bju.14249

    https://pubmed.ncbi.nlm.nih.gov/29645352/

Feedback from Our Patients

Dr Mohan has a great bedside manner and quiet confidence about him that puts you at ease. I first met him when he performed microwave ablation on my husband’s liver as part of his cancer treatment. One year later Dr Mohan did ablation laser therapy on my varicose veins.

Deborah Shearer

Dr. Mohan makes the most complicated and complex surgeries easy and fun for the patient. He is very caring and has impeccable “Bedside Manners” which is most comforting for an afraid patient. Can’t wait to visit him again. Thanks.

Thomas Axmacher

Dr. Mohamed Saved my life! The care leading up till I got accepted for my liver transplant was nothing but the best and most professional and at times difficult. Being the cancer had to be controlled and not spread through out it was just that… he controlled it, got rid of it, explained every procedure thoroughly.

William Gerardi